So I had them hooked up to my RME ADI-2 Pro FS like this for awhile... I can't remember the exact limitation, but I went back to the conventional analog connections. IIRC, it worked fine as a digital volume control, but there was a problem with either the headphone output toggling or the unbalanced output I send to my subwoofer. If you want, I can try it out again & see how it behaves.... I think I left an extra XLR cable run in place for it.
On a side-topic, I ended up contacting Harman-Pro again & sending the speakers to them for repair (the local shop was unresponsive). Got them back (very quickly too!) and everything seems fine now!