[No Politics] What you need to know about CoVID-19 by SARS-CoV-2 [No Politics]

[maty]

About hydroxychloroquine:

Governments and WHO changed Covid-19 policy based on suspect data from tiny US company
https://www.theguardian.com/world/2...-world-health-organization-hydroxychloroquine

 

[MarcT]

One thing that has made little sense to me is that:

1. I've read numerous times that experts think eating take out food is low risk because, among the reasons, even if a sick worker left virus on your food, ingestion of the virus doesn't seem like an easily viable path to infection (doesn't do well in digestive system, it wants the respitory system).

And yet:

2. We are continually admonished not to touch our eyes, nose and MOUTH with our hands, as these are paths to contact infection. Well then, what is it about touching our mouth that is that risky if ingesting the virus isn't an easy path to infection?

I think it depends on the inoculum to which you are exposed, or ingest. I was wondering about what the threshold is for becoming actively infected. I read that a few viral particles will not cause you to become infected and ill. As to food, any virus thereon would have to survive the acids in the intestinal tract. Does anybody have any info on the degree of inoculum one has to receive in order to become infected?

 

[maty]

About hydroxychloroquine:

Governments and WHO changed Covid-19 policy based on suspect data from tiny US company
https://www.theguardian.com/world/2...-world-health-organization-hydroxychloroquine

A mysterious company’s coronavirus papers in top medical journals may be unraveling
https://www.sciencemag.org/news/202...papers-top-medical-journals-may-be-unraveling

[ On its face, it was a major finding: Antimalarial drugs touted by the White House as possible COVID-19 treatments looked to be not just ineffective, but downright deadly. A study published on 22 May in The Lancet used hospital records procured by a little-known data analytics company called Surgisphere to conclude that coronavirus patients taking chloroquine or hydroxychloroquine were more likely to show an irregular heart rhythm—a known side effect thought to be rare—and were more likely to die in the hospital.

Within days, some large randomized trials of the drugs—the type that might prove or disprove the retrospective study’s analysis—screeched to a halt. Solidarity, the World Health Organization’s (WHO’s) megatrial of potential COVID-19 treatments, paused recruitment into its hydroxychloroquine arm, for example... ]


In my sources on twitter it has been discussed for days among the experts, some of whom sent a collective protest letter. Outlined in this thread days ago.

 

[Willem]

The head of virology in my university's medical school is convinced that the risks of outdoor infection are limited, unless large masses get close together and start singing etc. The risks indoors however are major. But how small is small and how large is large remains to be seen. It has certainly convinced me not to be too troubled by people on beaches or during peaceful demonstrations, but worry about churches, conventions, meat processing plants, trains, and sadly also university classes. We are now planning to have the bulk of our teaching online until Xmas.

 

[Willem]

it has been discussed for days among the experts

Dutch hospitals prescribed it for a while but abandoned it long before the Lancet article because they saw no benefits and were troubled by the side effects on about a third of their patients. It would be nice if they were wrong but I don't expect them to be.

 

[MarcT]

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31180-6/fulltext

Nuff said.

Do you still say this Lancet paper is "nuff said"?

As I replied at the time, no, that paper is not "nuff said", as it was immediately obvious that there were multiple issues with it. Now we are beginning to see how many questions there are about the data in that paper, as well as the one in NEJM. People eagerly and immediately accepted the Lancet paper as gospel and altered clinical trials and treatments for covid-19, based on those papers. Now we find out there were even more issues than were immediately apparent. Thanks to Maty for his posts today.

 

[maty]

The probability of contagion outdoors is 19 times less than indoors.

The problem is when groups are created that talk for a long time among themselves and without keeping distances, without masks or badly put on. Among young people it is quite common, at least around here.

People do not respect distances. And on the terraces, when the alcohol flows through the veins, they relax even more.

That is, walking and crossing people on the street the risk is minimal, except that you cough at that time. But in other circumstances ...

The logical thing, for me, is the obligatory nature of the mask on the street for a time and thus help to reduce the number of infections. Once it is very low, eliminate that obligation on the street. Then indoors.

When a regrowth is detected in an area, recover the obligation in addition to doing many tests and thus avoid confinements.

As long as they remain asymptomatic and no effective treatment in the early phase of the disease ...

 

[PierreV]

Do you still say this Lancet paper is "nuff said"?

As I replied at the time, no, that paper is not "nuff said", as it was immediately obvious that there were multiple issues with it. Now we are beginning to see how many questions there are about the data in that paper, as well as the one in NEJM. People eagerly and immediately accepted the Lancet paper as gospel and altered clinical trials and treatments for covid-19, based on those papers. Now we find out there were even more issues than were immediately apparent. Thanks to Maty for his posts today.

I'd still say yes. But I don't have local data to compare with as it was dropped here well before the paper appeared because of side effects and no results. Any paper in a hot and urgent situation will have methodological issue. Raoult himself saw his own paper retracted from his own magazine...

Edit: hadn't looked at the thing for a while, but yes, I have to concede that methodological issues are more severe than they initially appeared.

 

[maty]

Very good news. I advise entering the thread to read Pablo Fuente's notes on the article and use a Spanish translator.

https://twitter.com/i/web/status/1268201259372290049

https://twitter.com/i/web/status/1267933528555048961

Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates
https://www.biorxiv.org/content/10.1101/2020.05.28.121640v1

[ Abstract

The ongoing COVID-19 pandemic, caused by infection with SARS-CoV-2, is having a dramatic and deleterious impact on health services and the global economy. Grim public health statistics highlight the need for vaccines that can rapidly confer protection after a single dose and be manufactured using components suitable for scale-up and efficient distribution. In response, we have rapidly developed repRNA-CoV2S, a stable and highly immunogenic vaccine candidate comprised of an RNA replicon formulated with a novel Lipid InOrganic Nanoparticle (LION) designed to enhance vaccine stability, delivery and immunogenicity.

We show that intramuscular injection of LION/repRNA-CoV2S elicits robust anti-SARS-CoV-2 spike protein IgG antibody isotypes indicative of a Type 1 T helper response as well as potent T cell responses in mice. Importantly, a single-dose administration in nonhuman primates elicited antibody responses that potently neutralized SARS-CoV-2. These data support further development of LION/repRNA-CoV2S as a vaccine candidate for prophylactic protection from SARS-CoV-2 infection... ]

[PDF] https://www.biorxiv.org/content/10.1101/2020.05.28.121640v1.full.pdf

 

[LTig]

3 weeks ago he said on TV that at the beginning of June the Coronavirus would be history... he was right.

People in Brasil may have a different view.

 

[maty]

https://twitter.com/i/web/status/1268253059135819777

US: CoVid Tracking Dashboard
https://app.powerbi.com/view?r=eyJr...lMTQtNGRkNS1iMjE3LWE3NTBjNWIxMzIyZCIsImMiOjN9

 

[onofno]

About hydroxychloroquine:

Governments and WHO changed Covid-19 policy based on suspect data from tiny US company
https://www.theguardian.com/world/2...-world-health-organization-hydroxychloroquine

Extract :
"A Guardian investigation can reveal the US-based company Surgisphere, whose handful of employees appear to include a science fiction writer and an adult-content model, has provided data for multiple studies on Covid-19 co-authored by its chief executive, but has so far failed to adequately explain its data or methodology."

She's a stripper... (said on Sud radio yesterday at 12:15)

 

[onofno]

People in Brasil may have a different view.

Sure cause Professeur Raoult was talking about France...
Currently we live in France as before the confinement... however Museums are still closed.

 

[vert]

Extract :
"A Guardian investigation can reveal the US-based company Surgisphere, whose handful of employees appear to include a science fiction writer and an adult-content model, has provided data for multiple studies on Covid-19 co-authored by its chief executive, but has so far failed to adequately explain its data or methodology."

She's a stripper... (said on Sud radio yesterday at 12:15)

i.e. a porn actress? Say it ain't so!
The methodological issues look quite serious.
LOL

 

[onofno]

If you don't mind I'm going to tell you how to stay in very good health.

- don't drink cow milk and all products made with milk even a trace of milk. I don't. Animals don't drink milk when they are weaned.
- don't eat wheat. I don't.
- don't eat sugar but unrefined sugar from Brazil (called rapadura). Should be used in pastries and coffee.
- don't smoke. Yerkkk !
- walk 3km/day... I do.
- don't absorb antibiotics... I don't. They disturb your body. I can understand you will chose to absorb them... The word antibiotic comes from the greek "anti" that means "against" and the word "bio" that means "life" . So antibiotic means : against life. You can't fight viruses with antibiotics.
- you're taking one aspirin each day to stay in good health... are you serious ? Stop before it is too late...
- you're taking sleeping tablets ? Twenty years ago at least, I've spent 11 nights without sleeping and without taking sleeping tablets. The twelfth day and the following days I slept all night long. (but the twelfth day in the morning I've had a car accident because I was not awaken enough... hopefully nobody was injured...) Then, the more you'll take sleeping tablets the most difficult it will be finding a normal sleep. Could take months....
- stay away from vaccines - I do - but I can understand you won't do it... I've not got an injection or absorbed a product from Big Pharma since 1989.
- drink 1 liter of water/day if you can. I try to do it every day.
- drink espressos no more than 3/day. 100% Arabica Coffee from Brazil is one of the best. I drink 2/day.
- drink red wine or organic red wine (wines from California are VERY good but not like ours.................................................I'm teasing !)

I've probably forgotten something... I could add two lines today or tomorrow or...

 

[MarcT]

If you don't mind I'm going to tell you how to stay in very good health.
don't drink cow milk and all products made with milk even a trace of milk. Animals don't drink milk when they are weaned.
don't eat wheat
don't eat sugar but unrefined sugar from Brazil (called rapadura). I do. Can be used in pastries and coffee. I do.
don't smoke. Yerkkk !
walk 3km/day... I do.
stay away from vaccines - I do - but I can understand you won't do it... I've not got an injection or absorbed a product from Big Pharma since 1989.
drink 1 liter of water/day if you can. I try to do it every day.
drink espressos no more than 3/day. 100% Arabica Coffee from Brazil is one of the best.
drink red wine or organic red wine (wines from California are VERY good...)

I've probably forgotten something...

Hmm... then I should probably already be dead!

 

[MarcT]

I'm a bit surprised at the lack of commentary and analysis here about a possible second wave in the US, which might be spawned by the crowds of protesters, looters, and rioters currently roaming the streets of many large cities. And neither have I heard one word from the main media about the risk of gathering in these crowds. However, there was recently widespread alarm and outrage over people who had the temerity to visit the beaches and attend church, etc.

I'm just wondering what changed with respect to the pandemic, or if perhaps there is somehow less risk of transmission when you are out burning buildings down. I'm not trying to be snide here -- well, maybe a little, but it's a serious question. Thoughts on the risk of viral spread from these crowds?

Well, it's an anecdote, of course, but here's one! I wonder how many people he's gone on to infect after contracting the virus.

https://www.espn.com/college-footba...miga-tests-positive-coronavirus-tulsa-protest

 

[Thomas savage]

Hmm... then I should probably already be dead!

Dead and happy lol

 

[MattHooper]

If you don't mind I'm going to tell you how to stay in very good health.

- don't drink cow milk and all products made with milk even a trace of milk. I don't. Animals don't drink milk when they are weaned.
- don't eat wheat. I don't.
- don't eat sugar but unrefined sugar from Brazil (called rapadura). Should be used in pastries and coffee.
- don't smoke. Yerkkk !
- walk 3km/day... I do.
- don't absorb antibiotics... I don't. They disturb your body. I can understand you will chose to absorb them... The word antibiotic comes from the greek "anti" that means "against" and the word "bio" that means "life" . So antibiotic means : against life. You can't fight viruses with antibiotics.
- you're taking one aspirin each day to stay in good health... are you serious ? Stop before it is too late...
- you're taking sleeping tablets ? Twenty years ago at least, I've spent 11 nights without sleeping and without taking sleeping tablets. The twelfth day and the following days I slept all night long. (but the twelfth day in the morning I've had a car accident because I was not awaken enough... hopefully nobody was injured...) Then, the more you'll take sleeping tablets the most difficult it will be finding a normal sleep. Could take months....
- stay away from vaccines - I do - but I can understand you won't do it... I've not got an injection or absorbed a product from Big Pharma since 1989.
- drink 1 liter of water/day if you can. I try to do it every day.
- drink espressos no more than 3/day. 100% Arabica Coffee from Brazil is one of the best. I drink 2/day.
- drink red wine or organic red wine (wines from California are VERY good but not like ours.................................................I'm teasing !)

I've probably forgotten something... I could add two lines today or tomorrow or...

Dunno if that was a joke? Or just a dump of Bro Science?

I think you are on the wrong website ;-)

 

[MattHooper]

Dead and happy lol

And even: Healthy.

I've drank milk all my life and at 56 still drink it every day.
I loooove bread (and other carbs), and eat bread almost every day. If there's a bakery around, I'll find it.
Sugar? I don't treat it like The Devil. I enjoy sweat stuff, including even that devil spawn, sometimes sodas!

I've a BMI of 22, so not overweight. Recent spate of tests for physical: all health markers excellent. No chronic health issues, no medications.

For me, simple moderation-for-the-majority-of-the-week works. Not over-eating, and eating a variety of food. Being a foodie, I also enjoy "going wild" at a great restaurant too. Nothing held back. The whole anti-carbs thing (and anti-milk) leaves me rolling my eyes.

But, that's what seems to work for me. The problem I think comes when people do their thing to lose weight or be healthy, and then they just generalize to "here's how to eat/keep healthy!" Then you get people telling you DO THIS IF YOU WANT TO BE HEALTHY (or lose weight or whatever)! Within reason, it's an individual thing.