The APx555 for sure. This model? Not so much. A good DAC directly into a Cosmos ADC has enough headroom already to beat the APx516 on test here at at typical voltages. Add a Cosmos Scaler for low DUT output voltage measurements and you get close to or beyond the APx555.Nope. Cosmos works with both fixed input gain and high input impedance. The Scaler fix a bit of that, but it will never be as precise as an AP as it is. Not to mention, the limitation at 43Vrms to measure amplifiers (and most importantly, the gap between 10Vrms and 43Vrms, so you're working less precisely in this wide gap).
One thing the DIY chain does fall short on is high voltage output for low gain power amp testing, but again the Cosmos scaler goes up to 20Vrms balanced out, and isn’t needed on the measurement side for power amps, so can be repurposed.