The Intonas operate completely differently than the ADuM4166.
From the ADuM4166 datasheet:
Upstream and Downstream
Upstream and downstream refer to the directions of the data flow on the bus. Upstream means toward the higher tiers of the USB device hierarchy (closer to the USB host atop the hierarchy), and downstream means toward the lower tiers of the USB device hierarchy (farther from the host). ADuM4165/ADuM4166 include an upstream facing port (UFP) and a downstream facing port (DFP) to allow insertion into an existing connection between a DFP (connecting to UD+ and UD–) and a UFP (connecting to DD+ and DD–).
Hub
A hub is a USB device that provides additional connections to the USB, including at least one DFP. Typically, a standalone hub has a UFP that connects to the DFP of another device, and multiple DFPs of its own to expand the number of devices that can be connected to the USB. The combination of a single upstream connection to multiple downstream connections creates a star topology. Each additional hub connecting its UFP to another DFP of a hub adds a tier in the USB hierarchy. The ADuM4165/ADuM4166 add between one and two hub plus cable delays, and accordingly, for a device integrating the isolator into a UFP or a DFP, two fewer tiers can be added to the hierarchy for that isolated USB port.