Balanced design of AMPs/DACs makes signal go in 180degree phase in two wires, with third as ground, basically +/- are signals to reproduce by speakers, where unbalanced (regular RCA) simply two wires: ground and signal.
Usually balanced used in PRO equipment and provides better noise floor and SINAD. In my experience, Balanced designed equipment, especially amps with no volume control (fixed gain) provides superb channel separation and low channels cross talk.
But in the end, if Hypex 252MP been unbalanced, I would still buy it. Bought it because it is excellent AMP, not because it has balanced design.
I other words, there are great products that use unbalanced design. But if you will run long wires, or want superb channel separation / noise floor, usually that require balanced design (not always true though).
BTW any speaker by default balanced design. +/- signals.
Lets hear from maestro himself on that topic