The coaxial chassis performs similar in both orientations.
Erin has a video comparing the (smaller and older) R2c with the R3s. The R6 Metas have a better bass extension than the R2cs, but with subwoofers and eq the R3 would still be my favourite especially in terms of price/performance.
I'm currently considering replacing the center speaker and the two rear speakers. For the rear speakers my choice is 99% LS 50 Meta because there is a solid wall bracket available for them. I'm still thinking about the center. Listening distance is approx. 1.8m (6 ft), volume maximum 85-90 dBA, two subwoofers and the main speakers are available for the bass (eq with DLBC). I'm actually leaning towards a third LS 50 Meta and really unsure whether the almost 3 1/2 times price for the R6 Meta would be worth it for me.