Yes it's possible, but you have to keep the same waveguide design. However this speaker is designed as free space design and to be kept away from near by walls and reflective surfaces like the desk. For desktop speaker you're better of buying set of monitors specifically designed to stand on top the desk as they have specific switchable filters to counteract the boost in lower frequency band caused desktop placement.Is it possible to build this with a shallower but taller cabinet? I don't have a lot of desktop space.