Yes, he definitely should test them both ways. The room reflections will be quite different between the orientations.
For those unaware, the models being discussed are near-field monitors. Designed to be used close enough that their sound pressure overpowers accoustical reflections which are thus rendered moot, if you will.
As for for stand-mounting, using anything but the Genelec mounting plate will transmit vibration to the stand and also potentially back to the speaker. The Genelec plate is designed to work with the isopods.
Would that make a difference in satisfactory operation? Your mileage regarding vibrational resonances may vary. One could get out the accelerometers for testing... I'll just stick to the mounting plates.