Hmm, so you've asked another series of questions about more different combinations. I
think I've caught up.
So, the McIntosh amp. It's a poor feature set for the money. The DAC is not so hot. It has fixed band tone controls. It has so many unnecessary inputs.
It seems to me to be a dealer's amp rather than an end user's. The tone controls may or may not do something to recover from a poor speaker choice, but they won't help a lot with the room. You can use it to switch between lots of inputs, but so what, unless you actually own two turntables, a bunch of different line level devices you won't use most of the features. With the DAC, it's still not an all in one solution: but you are likely to use either a digital input to the DAC (so why pay for that array of analogue inputs) or you will use a good digital source into one pair of the balanced inputs in which case the DAC is redundant.
The multichannel downconversion? I can't tell, but it doesn't appear to be e-ARC, and there's a reasonable chance that you will be downconverting elsewhere anyway.
And with the speakers you are choosing (whichever it turns out to be, Kanta 2 or Sopra 1) you can save a chunk of money using the next model down MA-9500 - which will sound identical, by the way - if you do want or need some of those features, or the McIntosh look of the 12000. I can't see any reason not to do that, at least: and I would look further down the range for better value for money, personally. You don't have to give up the looks or sufficient power.
You already have a decent Yamaha amp, as discussed earlier, that you may need to check with the Focal speakers but is probably good enough: concentrate on a source with at least PEQ if not a full DSP solution, and the way to add the subs.
(For the benefit of new readers,
@dman777 has an A-S3200 amp and may be listening some of the time at close to 8m away from the speakers).
I just don't see how the MA12000 matches your needs, and suggest you reconsider.
The technical answer is that you won't destroy the speakers with the amp unless you push it very loudly, and you've told us that you probably won't. But you will carry less risk with the MA9500 for no loss whatsoever.