Hehe, audiophools will go to extremes to justify their purchases. In all honesty, the biggest issue in the audiophile world is cr@p loudspeakers. Just look at some of Amir's Klippel measurements! They're often voiced to grab the listener's attention in a short listening session, which usually results in them becoming fatiguing to listen to with extended playback. They then start looking further back in the chain to find 'smoother' source equipment to compensate.
Find a well-designed speaker (benign impedance, smooth frequency response, even directionality and power response etc. etc.), drive it with quality, neutral measuring source equipment and audio Nirvana is yours.
Most of the competent DIY speaker designs out there will substantially outperform commercial designs costing an order of magnitude more. Some of the DIY designers are incredibly skilled - they produce technically superb speakers that you can listen to all day. Drive them with well-measuring source equipment and you're sorted!
No 'system synergy' (aka compensating for one flaw with another flaw) required.