I don't have the DAC yet, so can't test it myself, but I have been able to run Topping Tune via the Whisky app which is a free implementation of Codeweavers version of Wine, all of these tools allow you to run Windows programs on Mac.
The UI of Topping Tune appears, but it is highly likely that it may not detect the USB device as it is not a native app and is running via Wine.
If you have the device you can give it a try though, I think Codeweavers has a free trial too.
I contacted Topping, and this was the response:
"Dear Sir/Madam
Thank you for contacting TOPPING support. We are happy to assist.
We are currently developing a Mac version of PEQ. Since the development process is quite challenging, it may take some time. We have registered your email, and once the Mac version is completed, we will notify you as soon as possible. ^.^
Best Regards,

[email protected]"
I think it's pretty obviously a canned response (probably AI-generated), but it gives some hope at least that Mac users can finally use the PEQ functionality without resorting to virtual machines/virtual PC apps.