I never feel like under-the-desk subwoofers integrate well with desktop speakers. (That is, if I'm sitting at the desk, as opposed to listening from across the room)
Maybe it's just me. It seems to be a popular arrangement.
It certainly didn't do the old Cambridge Soundworks PC Works 2.1 system from 20 years ago any favors in my ears, but then again the satellites were tiny cubes with 2.5" drivers, so the "sub" (5" I think) was more like a woofer and crossover may have been as high as ~200 Hz. Add boundary gain and room modes (
boom boom) so the sub had to be turned down plus whatever was lost by the desk being in the way, and you got a massive hole in the lower midrange that was obvious to me even then. I think that's quite a common problem with these, and part of the reason why people went back to 2.0s.
Eventually this system ended up on my nightstand, with satellites placed next to the "sub" and an old sock in the BR port. That was quite decent, actually. Still a slight loudness tendency, not infinite level handling, but quite pleasing. I have been wondering why on-desk "subs" never became more popular in these systems ever since.
I think you have to be able to cross a sub reasonably low (<100 Hz?) before under-desk placement works.
I know this monitor problem full well, and it's even worse here since my viewing distance is ridiculously short by most people's standards. I've been sticking with a 5:4 19" monitor with
good viewing angles. Pretty ideal aspect ratio for me tbh. Eizo make a 23.8" square model, for multiscreen applications I guess, but I doubt my neck muscles would appreciate something even higher. Not cheap either, they probably don't make them in huge numbers. You could place speakers between the monitors then though.