When I asked Xduoo if the TA-20 that comes stock with a pair of 12AU7's will operate correctly with 12AT7 / 12AX7 tubes, and they said they support all 3 tubes in the TA-20 under warranty. I've posted their responses to my questions I've asked them here in this thread before, you must have missed them.
Also, I've met someone recently that is running E80CC's in the TA-30 - and Xduoo said the same thing, that they support it under warranty.
And yes, I've checked the design documents and specifications for ECC81/ECC82/ECC83 12AU7/12AT7/12AX7 and more recently for the E80CC - all put out over many decades by numerous manufacturers and I see the optimal recommended component values, and that they all draw 12V 150mA - the E80CC draws 300mA, but if Xduoo says they can support these tube variations in their Hybrid headphone amplifiers under full warranty, I'm going to enjoy rolling the tubes, and listening to them.
It is clear Xduoo is doing some auto adjustment internally based on the gain of the Pre-amp tubes, so as to not overload the final SS amplifier. The 12AT7 and equivalents - like the Brimar 6060 Yellow "T"'s I am running right now sound more forceful and full, but the 12AX7's are a bit "hot" sounding, no distortion but you can tell the circuit is dealing with the higher gain - some may like it; I don't dislike it, but I prefer the 12AT7's for my listening.
When you design your own amp, your might want to check out the Xduoo designs first, for some tips on how to make it all work together, under warranty...
On second thought, you might as well buy one when they go on Sale during the Holidays, the TA-20 went for as low as $349, perhaps that will happen again this next holiday season.