Lurker first time poster, happy birthday to me.
1. I believe one of the main reasons of audio fatigue is, basically, that same case with OPs 128k mp3s, it just hits much later due to far more detailed sound.
Still, no matter how detailed the sound is, digital always sounds exactly the same. All the time. There will be a moment, sooner or later, when your brain knows every detail of your favorite soundtrack, and after that it will begin to grow fatigue.
2. I suspect, that's realy why people love tube amps/vinyl: not because of superior quality, but because distorted/randomly noisy anaologue sound helps them to escape fatigue.
3. Software solutions I tried/want to try
-android app for "vinylising" and "tuberising"
-adding something like rain simulators/ambient random generated noise
Rain and vinylising really helped.
And if I want to hear the music in all original lossless digital glory, I can always turn the soft off.
I mean I like to hear the music in original quality, but who can forbid me use some dirty tricks to escape fatigue if I want to?