On several occasions I've fired up my PC, started playing music, and found EqAPO lacking a "binding" to the currently active active device in Windows. I have two GPU's (each with 3x DP and 1x HDMI) and motherboard video (one more HDMI). So I have a bucketload of audio ports. I've found the "mappings" between the audio device in Windows and the physical port are not always stable. Driver updates, changing BIOS settings, anything that alters which display card Windows sees as "primary" and therefore places the logon screen, etc etc.
I'm only using EqAPO for sub/main xover so the consequences aren't as great. But if I'd been using EqAPO for woofer/tweeter xover with no protection cap I'd have killed 3-4 tweeters by now.