Research data disputes this. For one thing, i can tell you Pros are just as bad as audiophiles in detecting non-linear distortions. In one public blind test, one famous movie soundtrack mixer catastrophically failed a lossy compression test, saying two identical tracks sounded different! I was I think one of two people who found out the error in the test that resulted in identical files.
So if there is an implication in your post that pros have better ears when it comes to distortion, they do not.
On the rest of the point, a very careful study was performed recently with headphones. Once again, frequency response differences dominated and distortion except for extreme level in one sample I think, made no difference. Headphones naturally remove the room, and provide far higher acuity for detecting non-linear distortions.
It is a simple thing really: in presence of frequency response differences, distortion has no prayer of overriding those differences.
Now, if one is designing a speaker, they should make it as low a distortion possible as in that case, it is the same frequency response more or less.