I have very good experience with Topping HS02 isolator.I get varying levels of noise, a lot of it obviously centred around 'mains' frequency (50Hz) but also containing other random fizzing and crackling from the GPU (a problem for games) and USB mouse/keyboard. It's been intractable and obviously relates to the ground in the USB connection modulating the analogue signal, hence the desire to try a USB isolator.
With HS02 you don't need any unusual cables since it has 2 input ports.and 2-into-1 cable may be needed
The differences between HS01 and HS02 are described on HS02 product page https://www.tpdz.net/productinfo/953487.html