Assuming reasonable quality, there aren't much differences in cables that rise to the level of audibility. Even going with something like star-quad, yes it has the upside of better noise immunity, and the downside of loss of high frequencies, but unless the run is extremely long, neither comes into play.
What you do get with Mogami is a a cable that's among the tops in quality, but also is really pleasant to route and handle, while being reasonably durable. If rough treatment is a priority, maybe Canare is a slightly better bet, for instance, but when you're buying these brands it's never going to be a mistake. For the premium pre-made cables, of course you're paying a sizable premium for perceived robustness and detail. And if you're making them yourself, you're paying only a pretty slight premium of much lesser cables, but paying with your time (I'm assuming someone at that level has already paid for the soldering station and tools, for that and other reasons). And gaining customization.
Pretty much the same story with the connectors. Sure, you're paying a premium for Neutrik, but it's small per cable and you not only get a connector with good ergonomics, but it's easy to put it on the cable and has excellent strain relief. For those who buy a spool of cable and connectors and make their own, it's really a no-brainer to get something good (Mogami/Canare, Neutrik/Switchcraft), the premium over medicro is just not that much in total dollars, even when it it in percentage.
But the original question...the fancy versions of these cables boils down to convenience, interest, and price tolerance. I don't fault someone who's just paid $5k for some new audio gear, and there are a pair of sturdy and nice looking cables for $150 that the can grab off the rack and hook up when they get home, for overpaying. Well-made cables are comforting, and if you need to pay a little more to feel comfortable, there's no shame in that. Unless it's ludicrous, then you deserve a little shame.