Regarding big speakers, the key distance to the listener for any multi driver speaker is the distance the drivers integrate. The manufacturer can tell you that figure. Provided you can accommodate that distance the problem will be how to manage the bass, and in rooms, whether small or large, that presents difficulties. You seem to be on the right lines with the gear you've got - subs and MiniDSP.
You can check here to see the sort of problems that might arise:
Amroc Room Mode Calculator
Put in your room dimensions. Click the link 'more about Room Modes...' in the top right corner to get a better understanding of what is going on.
To improve the bass you do can any, all or a combination of these:
1. Change the listening and speaker positions.
2. Use room treatment (bass traps etc.).
3. Use DSP/EQ.
4. Use a sub or multiple subs.
I've not used MiniDSP or subs but there are surely others on here that have.
Firstly I would try to use what you've got, namely the two subs and MiniDSP.
The MiniDSP site shows how to connect everything:
https://www.minidsp.com/products/dirac-series/ddrc-24
You then have two things to deal with regarding the subs: the crossovers in MiniDSP and their volume, and their positioning to help with your bass problems. I understand this is quite difficult to get right.
You then need to measure with the MiniDSP to see how your are doing. Move chair, speakers and subs around a bit more and measure again. And again etc.. Of course you have to do this whilst still allowing your room to be practical to use.
Finally, once you find the best sounding and most practical positions, you can measure to get the flat curve frequency response or whatever curve you prefer.
That's the basics, but the details will be in the MiniDSP manual.