Afraid that long term comfort is quite an extremely subjective matter. It's not only the size but also the weight. On my ears they rest very steady and comfy and I believe to have midsized ears. I also have to say that I wear them exclusively with "audiophile" memory foam tips, therefore they're well planted in my ear canal and the cable has to provide just a minimum support from behind the lobe.Can you comment on long term comfort wearing them for extended period of time, especially the MP145 since their shell is quite large to accommodate its driver.
I agree with you that while many IEMs sound decent, only a few sound really, really good and correct, depending upon the drivers and configuration used.
Your mileage may vary.
On the Company's Discord I read all sort of comments ranging from the unlucky guy who had to return them because he has very small ears and couldn't accomodate the nozzles inside his ear canals even with the smallest tips to those complaining about the provided cable quality and shape and were trying to hack/remold it with lighters...
My suggestion would be to wait until they are available on Amazon and then get a pair from there. You like them, you keep them, you don't, you return them with no further annoyances. Buying directly from their site might help you spare some cash but if you don't like them you have to return them at your expenses to China.
As to their sound, paired with my Topping E30 MkI + Beyerdynamic A20 they sound full, balanced and detailed. Paired to the Hidizs DH80S DAC/Headphone amplifier they sound a (tiny) bit airier and detailed but a (tiny) bit lighter in the bass/subbass section.
In any case they are better detailed than the Truthear Zero. However please bear in mind that our ears are different and mine in particular are those of a 60-yrs old man who can't hear anything past 13kHz...