Lexus is a premium brand with premium costs. German brands with the exception of luxury brands, and even then only recently are not known statistically for their reliability. However NA and Europe brands all became much more reliable due to Japanese reliability pressure. They changed consumer expectations.
My German cars have been a series of air cooled VW Beetles (64, 67, 69, & three 71's all exceeding their original HP & Torque out put ratings by 30 to more than 100% [the 71 Super Beetle was the only one bought new, made the most power {105 HP} & got the best economy) & all made the 200K mark. As did my 1981 Mercedes 300D, 2004 Mercedes E320. American cars: 1968 SS396 Chevelle (low performance 325 HP [more like 375]), 1972 Ford Mustang Grande (351 Cleveland [least expected to go well over 200K did well over 300K], a 78 & a 79 Pontiac Trans/Am (both automatics) & a 79 4 speed manual Trans Am, 1982 Chevrolet Caprice (with a 2004R trans build at 50K, switched to a 700R4 at 80K) & all of the aforementioned did over 200K. Italian cars 71 Alfa Romeo Spyder, 68 Fiat 850 (neither made 150K). Japanese cars 2007 Honda Fit (bought new, sold due to leaving Guam) but still going with 60K on it), 2012 Lexus ES350 (bought new, which is the one with the computer problems, currently at 31K) and a currently owned 2000 Nissan Frontier 2.4 liter (right now 188K, nursing it along, it will need about 3 grand of work to keep going after 200K (body/trans/chassis ok, engine needs head gasket, valve refreshment, timing chain & tensioner kit with the sprockets and heater core) big expense but likely worth it.
The outliers for most overall expense are the Italian stuff, the Lexus & the Nissan Frontier (to be fair, a truck that gets used heavily as a truck).