While I haven't found this to be absolutely, I would point out a couple of things. First the better Eq systems will decrease the differences between center and L/R speakers and even the surrounds. Also better speakers tend to have flatter frequency responses. My experience is that while I do hear some differences between my Beta C250 center and KEF Q150 (Hardly surprising sonic differences between a coaxial and D'Appolito center in a desktop system!). It seems an obvious candidate for blind testing. My guess is most will notice the difference, but many will not be bothered by it. As a final note I have Infinity Modulus sat's as surrounds and have a full 'surroundscape' on recording that place instruments in the rear and sides such Steve Wilson's Yes remasters. I have a Denon AVR X-3300w with Audyssey XT32. I'll have to try listening to recording with it off and see if it affects the soundscape.