Try it, make a comparison and make your decision what to use. It is not about you seeing the benefits or not.But why not just use a twisted pair or even shielded cable to connect the input PCB with the signal detection circuitry directly to the amplifier module?
Why use a PCB to PCB connector, then a large PCB and then a ribbon cable with two more connectors on each end. I can’t see any benefit from those extra connectors and conductors.