The fatiguing part can be the amount (and tonality) of bass and/or the treble part.
To me the bass was too high and a bit too DT770 alike which has a 'one note bass' to me.
The partial sealing of the port improved the quality of the bass. It affects damping which EQ won't do.
This is really easy to experiment with using a piece of tape. Just make sure you have the exact same area covered on both cups.
It starts to affect the sound quite dramatically once you have covered about 3/4.
The treble (mount Beyer peak) was the worst offender. This can be EQ'ed.
I do not feel the need to fill-in the 2-5kHz peak (probably an ear-gain thing as I tend to prefer headphones with a bit less ear-gain)
The DT770 pads (the grey ones) differ from the DT1770 velour pads and liked it better with the grey pads but the treble peak is higher on those pads but filters out nice (with EQ)
The EQ needed differs between the DT770 and DT1770 velours pads.
So when using EQ I would lower the midbass peak and treble similar to the filter (so -8dB at 8kHz with the DT770 pads).
Perhaps just partially fill in the 2-5kHz dip (just 2 dB or so) when desiring a bit more clarity.
Haven't used the modified and filtered DT1770 in years though it is sitting in its case.
It was replaced for quite a while by a modified and filtered SRH940 with SRH1540 pads. I replaced the horrible quality headband. This headphone also has less ear-gain which seems to work for me.
measures like this:
I did not know that Shure could sound this good. The stock one is terrible in the treble.
Modified and filtered the response is very 'smooth' (no peaks/dips) which IMO is what makes the sound quality good.
These days I would recommend the OLLO S4R (1.2) or Austrian Audio Hi-X60 (with lower treble peak filter)
Have not heard/measured the DCA E3 yet but this one is 4x the price of the AA and OLLO and may be a bit too 'thick' and 'forward' for me. I do not seem to prefer the Harman tuning.