If they are hard drives, no, not appreciably. If they are SSDs, particularly older Samsungs of certain models (especially the 840 EVO, of which I own two), they will degrade and should be powered up periodically so that the data can be rewritten automatically in a process silently managed by the drives' firmware.Seriously, though, my original music server was in 1999, when I ripped nearly 1000 CD’s to mechanical hard drives. I have preserved all that data for 20 yeas via backup drives. With platter drives so cheap for the past 10 years, I replace them on schedules. That said, I hardly run the server drives now because of Tidal’s selection, so they get minimal run time. I have two older drives that I keep stored - query, does the data degrade from just sitting there?