What are the limits? I suppose if there are speakers available that you are familiar with to compare to, then you have an understanding of how those you are familiar with sound in your space, can hear how they sound in the room you are auditioning in and from there roughly gauge what other speakers would be of interest/sound like in your room.
Not sure if I understand what you mean. If I listen to familiar music on speakers in a room with reasonable acoustics, it's not impossible to judge the qualities of said speakers.
If one has good understanding of how acoustics affect speakers, that is helpful to better understand the quality of the speaker. If one has zero understanding of how acoustics affect speakers, it's more likely that you conclude wrongly about the speaker quality.