It doesn't which is why I don't quite understand the preamp discussion unless the OP has an analog x-over downstream of the DAC, although that would somewhat defeat the purpose of having a 4 channel DAC.
As the OP is starting from a 4 channel DAC any stereo amplifier will be fine, even if they do not have a line out.
Assuming you care about total system noise gain absolutely matters as it determines how much the noise from the upstream device is multiplied. While the MOTU M4 is relatively low noise it is not SOTA so it makes sense to pay attention to gain. If you run the numbers with both the PA5 and NC252MP amplified DAC noise is the biggest contributor to system noise, this is why the comparison of amplifier residual noise that
@NTK posted earlier doesn't tell the whole story.
Michael