No offence but I don't agree with that at all. All equipment in my test is brand new and tubes are from a valid source, and the difference is cat and dog! There are very large audible differences as well as subtle in the sound from tube to other tube. Its also a widely agreed and known fact across the entire planet.
You know... Transistors & MOSFETs have "tolerances" too.
But, usually the circuit is designed to be independent of these variations. Occasionally you might have a bias adjustment, but that's usually a one-time factory adjustment, or an adjustment if you have to replace a part. With tubes you might have to re-adjust the bias as the tube ages.
The same concepts CAN be used in a tube design, or it can be designed to behave differently with tube variations.
IMO - A good design should be stable. ...I'll bet McIntosh tube amps don't change as the tube ages, or if you change tubes, as long as the tube remains within its specified tolerances.
Guitar amps are a different story. They are designed to have "tube sound" (not high
-fidelity) and they can be intentionally sensitive to tube swapping. Some "audiophile" amps may also be designed for "tube sound"... Also not high-fidelity.