What you need to know about the virus in China "2019 Novel Coronavirus (2019-nCoV)"

[DKT88]

접수부터 의료진 면담, 체온 측정, 코와 입의 검체 채취까지 10분 안에 가능하다.
https://m.news.naver.com/read.nhn?mode=LSD&mid=sec&sid1=102&oid=025&aid=0002979097

Not the test result. But everything before that can be done in 10 min.

After test we go home and wait for the results to come

세종시는 "그동안 의심환자 등을 한 명 검사할 때마다 진료실을 소독해야 해 검체 채취까지 30분 이상 걸렸지만, 드라이브 스루 방식을 도입해 시간을 줄일 수 있을 것"이라고 밝혔다.

It did shorten the waiting line. The wait in tent method did take longer

PS. 세종시 is not persons name. It is http://www.sejong.go.kr/ yup ‘go.kr’

Reducing the waiting in a clinic around people who are sick enough to show up for testing is hugely important. I'm thinking that it may be better to stay here in Korea and ride it out in my apartment than jump from the pan into the fire.

 

[sweetchaos]

접수부터 의료진 면담, 체온 측정, 코와 입의 검체 채취까지 10분 안에 가능하다.
https://m.news.naver.com/read.nhn?mode=LSD&mid=sec&sid1=102&oid=025&aid=0002979097

Not the test result. But everything before that can be done in 10 min.

After test we go home and wait for the results to come

세종시는 "그동안 의심환자 등을 한 명 검사할 때마다 진료실을 소독해야 해 검체 채취까지 30분 이상 걸렸지만, 드라이브 스루 방식을 도입해 시간을 줄일 수 있을 것"이라고 밝혔다.

It did shorten the waiting line. The wait in tent method did take longer

PS. 세종시 is not persons name. It is http://www.sejong.go.kr/ yup ‘go.kr’

Thank you. The western media sometimes *misinterprets* the situation. Cheers!
I've fixed my original post.

 

[sweetchaos]

Same reporter now says:

There are plans to expand drive-thru coronavirus clinics across South Korea, according to Yonhap. Currently there are drive-thru’s in Goyang near Seoul, Sejong, and here’s the pic we got of the drive-thru in Daegu. Whole process takes 10mins. No need to get out of car.

 

[andymok]

I'm going without any face mask unlike some Asians I see when I am out and about. I'm leaving it up to nature. I survived the very very nasty swine flu of the late 1960's and early 1970's, measles, mumps, many bouts of pertussis and pneumonia and some really nasty flues of which I am supposed to be vaccinated for (cross fingers). If I make it I make it

You can choose whatever you like, but the poor guy infected by you accidentally are gonna think otherwise.

Don't get me wrong, I live in HK and I'm OK with not wearing mask IF they're fully aware of the risk and act accordingly, like keep spacing and not going to crowded areas.

 

[andymok]

the world can worry about the origin of the virus later, much bigger fish to fry at this point than whether it came from a bio lab or a seafood market. Barn door is open. I'm here in South Korea surrounded by the outbreak and I can tell you we don't care about conspiracy theories today. We are more interested in practical survival.

Exactly, live long enough and we'll know.

 

[RayDunzl]

In other news...

Everyone in China has been ordered to place themselves under arrest:

In Louisiana they could easily combine the drive through coronavirus tests with the local Drive Through Daquiri Stands.

 

[DKT88]

I'm going without any face mask unlike some Asians I see when I am out and about. I'm leaving it up to nature. I survived the very very nasty swine flu of the late 1960's and early 1970's, measles, mumps, many bouts of pertussis and pneumonia and some really nasty flues of which I am supposed to be vaccinated for (cross fingers). If I make it I make it

You can choose whatever you like, but the poor guy infected by you accidentally are gonna think otherwise.

Don't get me wrong, I live in HK and I'm OK with not wearing mask IF they're fully aware of the risk and act accordingly, like keep spacing and not going to crowded areas.

I think you are right, masks primarily purpose is to pr

I'm going without any face mask unlike some Asians I see when I am out and about. I'm leaving it up to nature. I survived the very very nasty swine flu of the late 1960's and early 1970's, measles, mumps, many bouts of pertussis and pneumonia and some really nasty flues of which I am supposed to be vaccinated for (cross fingers). If I make it I make it

As I understand it, the purpose of the face mask is to (minimally) protect others around you. Not much good for your personal protection. Unfortunately many think it provides protection for the wearer.

 

[g29]

What information? The complete genetic sequence is available https://www.ncbi.nlm.nih.gov/genbank/sars-cov-2-seqs/ . What information are you talking about? What countermeasures, specifically, are you talking about?

How it was created and how to neutralize it. (if it was created and if they have some sort of vaccine, antidote, drug therapy, etc.).

There were multiple reports that it has genome similarities to HIV/AIDS and that some in China were using HIV drugs to treat it.

Stunning Finding: S-Protein Insertions From HIV

On Jan. 27, 2020, Prashant Pradhan et. al. from the Indian Institute of Technology published a paper entitled “Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag,” which is currently being revised. The corresponding author of this paper, Professor Bishwajit Kundu, is specialized in protein genetic and genetic engineering and has published about 41 papers during the past 17 years on PubMed, including high-impact biomedical journals.

The authors found 4 insertions in the spike glycoprotein (S) which are unique to the 2019-nCoV and are not present in other coronaviruses. “Importantly, amino acid residues in all 4 inserts have identity or similarity to those of HIV-1 gp120 or HIV-1 Gag. Interestingly, despite the inserts being discontinuous on the primary amino acid sequence, 3D-modelling of the 2019-nCoV suggests that they converge to constitute the receptor binding site. The finding of 4 unique inserts in the 2019-nCoV, all of which have identity/similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature.”

Pradhan et al. added, “To our surprise, these sequence insertions were not only absent in S-protein of SARS but were also not observed in any other member of the Coronaviridae family. This is startling as it is quite unlikely for a virus to have acquired such unique insertions naturally in a short duration of time.”

“Unexpectedly, all the insertions got aligned with Human immunodeficiency Virus-1 (HIV-1). Further analysis revealed that aligned sequences of HIV-1 with 2019-nCoV were derived from surface glycoprotein gp120 (amino acid sequence positions: 404-409, 462-467, 136-150) and from Gag protein (366-384 amino acid). Gag protein of HIV is involved in host membrane binding, packaging of the virus and for the formation of virus-like particles. Gp120 plays crucial role in recognizing the host cell by binding to the primary receptor CD4. This binding induces structural rearrangements in GP120, creating a high affinity binding site for a chemokine co-receptor like CXCR4 and/or CCR5.”

It is well known that CD4 cells are essential to human immunity and are the direct targets of the Human Immunodeficiency Virus or HIV. HIV attaches to CD4 cells, enters and infects them. The virus then turns each infected CD4 cell into a factory creating more HIV virus until eventually all CD4 cells are destroyed. People infected with HIV lose their immunity or defense system which is like a country losing the function of its army.

If we take a closer look at the 4 insertions of the S-protein in figure 3 (from Pradhan et. al. 2020 bioRxiv), they are all located on the binding surface of the protein, seemly designed to be able to bind to target cell receptor sites. Natural accidental mutation would be randomly distributed across the whole length of the S-protein. It is highly unlikely that all of these insertions would coincidentally be manifested on the binding site of the S-protein.

The article by Pradhan et. al. is a preprint made available through bioRxiv and has not been peer-reviewed.

bioRxiv reports: “This paper has been withdrawn by its authors. They intend to revise it in response to comments received from the research community on their technical approach and their interpretation of the results. If you have any questions, please contact the corresponding author.”

...

The United States Centers for Disease Control stated: “There is no specific antiviral treatment recommended for 2019-nCoV infection.” But, there are a few case reports of Wuhan 2019-nCoV patients benefiting from empiric treatment with anti-HIV drugs such as lopinavir. More such detailed clinical experience needs to be shared.

 

[RayDunzl]

"Chinese city gives residents up to $1,400 for reporting novel coronavirus symptoms
The city of Qianjiang, in China's Hubei province, is awarding residents who proactively report symptoms associated with the novel coronavirus.

Any resident who reports symptoms and is confirmed to have the novel coronavirus will be awarded 10,000 yuan — or about $1,426 — according to a Qianjiang government press release.

Meanwhile, patients who come forward and are classified as "suspected cases" will be rewarded 2,000 yuan (or $285). Those that are not immediately confirmed to have the illness upon first diagnosis will be rewarded 1,000 yuan ($142).

The new incentives came into force Thursday."


Another source:

https://www.reuters.com/article/us-...ients-who-report-to-authorities-idUSKCN20L0GE

 

[DKT88]

How it was created and how to neutralize it. (if it was created and if they have some sort of vaccine, antidote, drug therapy, etc.).

There were multiple reports that it has genome similarities to HIV/AIDS and that some in China were using HIV drugs to treat it.

Stunning Finding: S-Protein Insertions From HIV

This source, the Epoch Times, is questionable. There "are multiple reports" is not science or a reference. What, other than Epoch Times are the reports?

 

[Wombat]

A

In other news...

Everyone in China has been ordered to place themselves under arrest:

View attachment 52046

In Louisiana they could easily combine the drive through coronavirus tests with the local Drive Through Daquiri Stands.

View attachment 52047

The US is well populated with drive-through outlets. Convenient temperature taking test sites?

 

[andymok]

There were multiple reports that it has genome similarities to HIV/AIDS and that some in China were using HIV drugs to treat it.

Stunning Finding: S-Protein Insertions From HIV

Just because your name is David, and it spells as such, it doesn't make you a member of the Beckham family.

and no, as much I hate the HKSAR govt, Epoch Times is not a reliable source.

 

[g29]

This source, the Epoch Times, is questionable. There "are multiple reports" is not science or a reference. What, other than Epoch Times are the reports?

Just because your name is David, and it spells as such, it doesn't make you a member of the Beckham family. and no, as much I hate the HKSAR govt, Epoch Times is not a reliable source.

The Epoch Times didn't write the medical paper, they just reported on it as well as did other news outlets. The source of the information is the following. If you don't agree with the information, discredit the source, don't shoot the messenger who was NOT the author of the paper's content.

"On Jan. 27, 2020, Prashant Pradhan et. al. from the Indian Institute of Technology published a paper entitled “Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag", which is currently being revised. The corresponding author of this paper, Professor Bishwajit Kundu, is specialized in protein genetic and genetic engineering and has published about 41 papers during the past 17 years on PubMed, including high-impact biomedical journals.

A quick internet search will show many sites that have published this paper.

Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag

...
Conclusions

Our analysis of the spike glycoprotein of 2019-nCoV revealed several interesting findings: First, we identified 4 unique inserts in the 2019-nCoV spike glycoprotein that are not present in any other coronavirus reported till date. To our surprise, all the 4 inserts in the 2019-nCoV mapped to
short segments of amino acids in the HIV-1 gp120 and Gag among all annotated virus proteins in the NCBI database. This uncanny similarity of novel inserts in the 2019- nCoV spike protein to HIV-1 gp120 and Gag is unlikely to be fortuitous. Further, 3D modelling suggests that atleast 3 of the unique inserts which are non-contiguous in the primary protein sequence of the 2019-nCoV spike glycoprotein converge to constitute the key components of the receptor binding site. Of note, all the 4 inserts have pI values of around 10 that may facilitate virus-host interactions. Taken together, our findings suggest unconventional evolution of 2019-nCoV that warrants further investigation. Our work highlights novel evolutionary aspects of the 2019-nCoV and has implications on the pathogenesis and diagnosis of this virus.

References

Beniac, D. R., Andonov, A., Grudeski, E., & Booth, T. F. (2006). Architecture of the SARS coronavirus prefusion spike. Nature Structural and Molecular Biology, 13(8), 751–752. https://doi.org/10.1038/nsmb1123

Biasini, M., Bienert, S., Waterhouse, A., Arnold, K., Studer, G., Schmidt, T., Kiefer, F., Cassarino, T. G., Bertoni, M., Bordoli, L., & Schwede, T. (2014). SWISS-MODEL: Modelling protein tertiary and quaternary structure using evolutionary information. Nucleic Acids Research. https://doi.org/10.1093/nar/gku340

Bosch, B. J., van der Zee, R., de Haan, C. A. M., & Rottier, P. J. M. (2003). The Coronavirus Spike Protein Is a Class I Virus Fusion Protein: Structural and Functional Characterization of the Fusion Core Complex. Journal of Virology, 77(16), 8801–8811. https://doi.org/10.1128/jvi.77.16.8801-8811.2003

Chan, J. F.-W., Kok, K.-H., Zhu, Z., Chu, H., To, K. K.-W., Yuan, S., & Yuen, K.-Y. (2020). Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerging Microbes & Infections, 9(1), 221–236. https://doi.org/10.1080/22221751.2020.1719902

Chan, J. F. W., Lau, S. K. P., To, K. K. W., Cheng, V. C. C., Woo, P. C. Y., & Yuen, K.-Y. (2015). Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease. https://doi.org/10.1128/CMR.00102-14

Chan, J., To, K., Tse, H., Jin, D., microbiology, K. Y.-T. in, & 2013, undefined. (n.d.). Interspecies transmission and emergence of novel viruses: lessons from bats and birds. Elsevier. Corpet, F. (1988). Multiple sequence alignment with hierarchical clustering. Nucleic Acids Research. https://doi.org/10.1093/nar/16.22.10881

DeLano, W. L. (2002). The PyMOL Molecular Graphics System, Version 1.1. Schr{ö}dinger LLC. https://doi.org/10.1038/hr.2014.17

Du, L., Zhao, G., Kou, Z., Ma, C., Sun, S., Poon, V. K. M., Lu, L., Wang, L., Debnath, A. K., Zheng, B.-J., Zhou, Y., & Jiang, S. (2013). Identification of a Receptor-Binding Domain in the S Protein of the Novel Human Coronavirus Middle East Respiratory Syndrome Coronavirus as an Essential Target for Vaccine Development. Journal of Virology, 87(17), 9939–9942. https://doi.org/10.1128/jvi.01048-13

Edgar, R. C. (2004). MUSCLE: Multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Research. https://doi.org/10.1093/nar/gkh340

Elbe, S., & Buckland-Merrett, G. (2017). Data, disease and diplomacy: GISAID’s innovative contribution to global health. Global Challenges. https://doi.org/10.1002/gch2.1018

Kirchdoerfer, R. N., Cottrell, C. A., Wang, N., Pallesen, J., Yassine, H. M., Turner, H. L., Corbett, K. S., Graham, B. S., McLellan, J. S., & Ward, A. B. (2016). Pre-fusion structure of a human coronavirus spike protein. Nature. https://doi.org/10.1038/nature17200

Kumar, S., Stecher, G., Li, M., Knyaz, C., & Tamura, K. (2018). MEGA X: Molecular evolutionary genetics analysis across computing platforms. Molecular Biology and Evolution. https://doi.org/10.1093/molbev/msy096

Li, F. (2016). Structure, Function, and Evolution of Coronavirus Spike Proteins. Annual Review of Virology, 3(1), 237–261. https://doi.org/10.1146/annurev-virology-110615-042301

Murakami, T. (2008). Roles of the interactions between Env and Gag proteins in the HIV-1 replication cycle. Microbiology and Immunology, 52(5), 287–295. https://doi.org/10.1111/j.1348-0421.2008.00008.x

Ou, X., Guan, H., Qin, B., Mu, Z., Wojdyla, J. A., Wang, M., Dominguez, S. R., Qian, Z., & Cui, S. (2017). Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1. Nature Communications. https://doi.org/10.1038/ncomms15216

Snijder, E. J., van der Meer, Y., Zevenhoven-Dobbe, J., Onderwater, J. J. M., van der Meulen, J., Koerten, H. K., & Mommaas, A. M. (2006). Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex. Journal of Virology, 80(12), 5927–5940. https://doi.org/10.1128/JVI.02501-05

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Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W., Lu, R., Niu, P., Zhan, F., Ma, X., Wang, D., Xu, W., Wu, G., Gao, G. F., & Tan, W. (2020). A Novel Coronavirus from Patients with Pneumonia in China, 2019. New England Journal of Medicine, NEJMoa2001017. https://doi.org/10.1056/NEJMoa2001017
...

 

[andymok]

The Epoch Times didn't write the medical paper, they just reported on it as well as did other news outlets. The source of the information is the following. If you don't agree with the information, discredit the source, don't shoot the messenger.

Messenger takes orders. No one is ordering them to message anything, not to mention they do not have a big brother watching them.

Media Studies was part of my training, if I had to shoot I'll make sure shooting them all over the place. Coz they're "supposed" to be journalists, not pigeons.

Sorry if my tone is bit too heavy, such "fake" news in a 8M city is not helping, it's also devastating. Lack of critical thinking causes public panic and it's really no joke, people act on fear and pure instincts could just be like zombies of another kind.

 

[g29]

Messenger takes orders. No one is ordering them to message anything, not to mention they do not have a big brother watching them.

Media Studies was part of my training, if I had to shoot I'll make sure shooting them all over the place. Coz they're "supposed" to be journalists, not pigeons.

Sorry if my tone is bit too heavy, such "fake" news in a 8M city is not helping, it's also devastating. Lack of critical thinking causes public panic and it's really no joke, people could act on pure instincts just like zombies of another kind.

Again, you failed to address the contents of the original medical paper which I linked to for your convenience (and by your response, appearant avoidance). Either read the paper and address its data and information directly to contribute to the discussion, or continue your irrelevant rant against a single outlet (one of many) that reported it.

 

[andymok]

I don't do quick internet search, I usually go through at least 5 pages of results on Google in a single search, for 3+ non-cross referencing, original independent analysis. If I can't find it on Google, I'll go for Google Scholar / Google Patents

Basic media training, always read/hear from both sides.

Coronavirus Project - Federation of American Scientists
https://fas.org/ncov/#1581534080787-1893525f-dbef

HIV-1 did not contribute to the 2019-nCoV genome - Journal, Emerging Microbes & Infections, Volume 9, 2020 - Issue 1
https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1727299

"Baseless Conspiracy Theories Claim New Coronavirus Was Bioengineered" - FactCheck.org
https://www.factcheck.org/2020/02/b...ries-claim-new-coronavirus-was-bioengineered/

Protein structure and sequence re-analysis of 2019-nCoV genome does not indicate snakes as its intermediate host or the unique similarity between its spike protein insertions and HIV-1 - Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA
https://arxiv.org/ftp/arxiv/papers/2002/2002.03173.pdf

 

[NTK]

Again, you failed to address the contents of the original medical paper which I linked to for your convenience (and by your response, appearant avoidance). Either read the paper and address its data and information directly, or continue your irrelevant rant against the a single outlet (of many) that reported it.

Did any of them say that the paper was withdrawn?

 

[andymok]

Did any of them say that the paper was withdrawn?

View attachment 52101

Academic papers get published for many reasons. Rushing and Getting attention on their findings, "Let others review for them" were part of it. Not saying they deliberately do so, but these things just happen.

 

[g29]

Did any of them say that the paper was withdrawn?

View attachment 52101

The original EpochTimes article posted updated its article with that information.

[bioRxiv reports: “This paper has been withdrawn by its authors. They intend to revise it in response to comments received from the research community on their technical approach and their interpretation of the results. If you have any questions, please contact the corresponding author.”

Looks like they are responding to peer reviews.

 

[g29]

Academic papers get published for many reasons. Rushing and Getting attention on their findings, "Let others review for them" were part of it. Not saying they deliberately do so, but these things just happen.

The EpochTimes article specifically stated it had not been peer reviewed yet and was awaiting peer review. They even updated their article with the preceding. I take that as full disclosure as well as followup on their part.