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This is the best way to connect the E3 with 2.5mm jack to the RMEThanks, but I already have a used E3 with balanced 2.5 mm cable on the way
The RME ADI 2 DAC FS is not a balanced headphone amp (nor does it need to be) but converting balanced headphone to single ended amp is not a problem using such adapters. You CANT connect a single ended headphone (so 3.5mm or 6.35mm plug) to a balanced headphone amp even with adapters (so 2.5, 4.4, balanced XLR)