Typically you'd use many tubes in parallel in an OTL (output transformerless) amp where you basically parallel a whole lot of tubes and add a crapload of global feedback to try to lower output impedance and then you pretend that the output impedance is low enough to drive a speaker directly without a transformer and sell it to the unsuspecting public.
This is because tubes are rather high impedance devices.
What OTL speaker amps do best is explode spectacularly and burn up your speakers, if you're really not lucky.
They will make sound come out of the speakers occasionally, when they are working.
OTL amps for headphones are common and work decently well with high impedance headphones because the pretending part is taken out of the equation.
In the olden days, there were high impedance speakers made to accommodate OTL amps.
OTL amps mostly came about because of the weight saving effect of eliminating all that output iron.