I am pretty sure the D50 supports 44.1 KHz at 16 bits, but I cannot select that combo using either the Midi Setup app in Mac OS or Bitperfect.
I cannot post a picture right now, but the Audio Midi Control app lists all of the possible sample rates in the usual step increases starting at 44,100 Hz all the way up to 768,000 Hz, it just does not show all the usual bit-depths (16, 24, 32), it only shows 24 and 32. The 16-bit resolution is not shown. If I launch Bitperfect, I can force 44.1/16, but Bitperfect will surprisingly report it is configured for 44.1 KHz / 0 bits (your read that right! zero bits!) and that is what I can see before I start playing music. As soon as I hit play, on iTunes, Bitperfect crashes. So, for now, I am using 44.1 KHz at 24 bits.
I am not complaining about the sound though, let me make that abundantly clear, I would just like to know if there is any particular setting I should be using that would be better for the D50 since I cannot choose 44.1 KHz at 16 bits (although now I understand that if I am using core audio this is exactly what could be happening behind the scenes).
Still, I will create a new Windows partition tonight (hopefully) and report to you, all, what happened. Also, I am not familiar with the mpd or cmus players, but now I am interested.