The front panels of speaker amps sometimes use their own speaker amp output to the headphones. To reduce noise and power they use a dropping resistor which can increase the impedance. This can cause variations in interactions with the headphones. So in that aspect, it's not the same. Of course there's nothing stopping using an actual separate headphone amp inside the speaker amplifier to power it.
The Emotiva A-100 is a godo example. its default mode is a dropping resistor which raises impedance to 220 ohms and reduces noise. They state that this resistor can cause variations similar to "vintage gear". Their direct drive mode involves inserting a jumper to bypass it unleashing the full power of the amp with a much lower impedance but at the expense of increased noise. So with the wrong combo, in direct drive mode you can get audible hiss, and in stock mode you can get uneven driving of the headphone drivers.