Depends on what you mean. As long as you're using a shared backend such as MME, DirectSound or WASAPI Shared, then yes, you can have multiple FlexASIO instances running to the same device. But there's nothing particularly interesting about that: in that mode FlexASIO emulates a typical (e.g. DirectSound) Windows application, and goes through the entire Windows audio stack (including the Windows mixer). Therefore it's completely unsurprising that it supports multiple clients per device. It would be misleading to say that this is a way to do "multiple ASIO to the same device" since FlexASIO (just like ASIO4ALL) is a universal ASIO driver, i.e. it's an emulation layer, not a "true" ASIO driver (such as one that would be provided by the audio device manufacturer).
When using WDM-KS (either in FlexASIO or in ASIO4ALL), things get a bit more interesting because, AFAIK, there are devices out there that make it possible to run multiple KS streams at the same time to the same endpoint - it's hardware mixing, basically. It was all the rage in the days before Windows Vista (hardware audio acceleration), but I don't know if you can still do that in modern Windows versions. The reason why that's interesting is because it makes it possible to run a bit-perfect, but not necessarily exclusive, pipeline to the hardware. I've never tried it, though.
Following a similar principle, it is theoretically possible for an audio manufacturer to provide a "native" ASIO driver that allows multiple ASIO applications to use the same endpoint. That would require them to implement some kind of mixing capability either in the driver or in the hardware. I doubt any manufacturer would bother, though.
To put a different spin on that question, keep in mind that in general you can't use multiple ASIO drivers (or multiple instances of the same driver) at the same time from the same ASIO Host Application process. That's a silly limitation of the ASIO Host API, which uses global state all over the place. I suspect there are ways for application developers to circumvent that limitation through clever workarounds, but I don't know if anyone bothered.