could AI take everything we know and do better than a human designer ?
IMO yes and no.
"AI" of the generative LLM type that's been in the news lately - no. It's not especially good for that type of work. It creates things that seem right (and by virtue of seeming right very accurately, often are right) but can't evaluate whether something is actually right or not.
"AI" of a "genetic algorithm / machine learning" type, which has actually been around for a few years, probably could. This is akin to multi-physics goal-seeking optimizer / solvers that are already available in packages like COMSOL. It could iteratively simulate a large number of possible designs and compare them to a goal performance spec.
This takes a hell of a lot of computing power but there's nothing stopping us from designing a speaker that way, in principle.
Why it can't actually design "the perfect speaker":
Speaker performance is already pretty good and is largely limited by the performance of materials that go into the speaker. The designs of drivers are pretty efficient and close to the limits of physics in many cases. Voice coils are an old technology that's quite mature.
Totally novel technologies could be in scope for a "genetic algorithm" of some kind, but the competition is very steep already, and the laws of physics don't change just because AI is involved.
Also, "the perfect speaker" is a subjective notion, in real life. What IS the perfect speaker? Tell us your definition and we can have a more detailed conversation about whether AI can achieve it. However, my prediction is once you define your perfect speaker, the thread will instead devolve into an argument about what "perfect speaker" means... it always does.