In the end, it seems like the drug-music connection is about achieving some kind of immersed meditative state of flow and attention. I’m sure it can be achieved without assistance - but with a lot of practice.
Linking to this because it is topical to my comment:
For those that have read Casteñeda, regardless of how you view his work, one point he wrote that the psychedelic properties of what he "set out to study" change the "speed" that your awareness operates at.
This is akin to other writings I've been exposed to that discuss the "mental filters" on our perception.
Some adepts are able to enter a state of heightened awareness without any aids; others require the assistance of a chemical boost. Regardless of the specific culture, one can find the evidence for this far and wide throughout the history of any Shamanic culture including ancient China prior to (or perhaps in proximity to) the development of their more spiritual/mystical "religious" offshoots.
There are many documented paths of seeking wisdom that allude to ingesting various substances commonly seen as toxic by today's standards.
However true or not... these all commonly relate to a practice in human civilization where we sought out mysticism and freely practiced it. Of course, in "polite" society, the concept of mysticism is frowned upon at best, or outright shunned as abhorrent or otherwise taboo in the manner of witchcraft or magick.
Where some would claim sacrament, others claim hedonism. Where some find higher purpose, others find escape.
Where are the boundaries set and who gets to decide such for the individual?