Now that I've spent a couple days finally playing around with a MiniDSP in concert with REW, I have a larger appreciation for what software like Audyssey XT32 can do, especially for those sorely lacking in patience (/eagerly raises hand). In my room, I have not yet been able to appreciably best in a few hours what XT32 does in minutes. After making several tweaks to my dual subs within the MiniDSP and then running Audyssey, REW actually showed a very nice plot (slightly smoother than prior). However, in listening to some bass-heavy material, something was clearly missing. Fireworks exploded with a sort of flappy FFFFPPT noise. Yeah, the couch shook a little bit, but is this really what "correct" bass sounds like? Surely not. I removed the MiniDSP from the chain and went back to using both sub outputs from my Denon, and - BOOM, proper fireworks again! Of course it turns out I was overdriving the MiniDSP into clipping. So, while obviously not an insurmountable problem, I've now introduced yet another variable into the system that needs to be carefully accounted for, monitored, and adjusted.
Of course, Audyssey is not without its quirks and the companion app is virtually mandatory, but at the end of the day if it's getting my system ~90% of the way there with ~500% less effort, that seems acceptable to me. Prior generation (and better-measuring than current) Denon AVRs have recently plummeted in price. It does seem counterproductive to discount such an appealing cost-to-effort ratio because it includes "extra stuff".