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Snake Oil Department, Top This
- Thread starter Ron Texas
- Start date
Killingbeans
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One of my classmates tried something similar. Only, it resulted in a pulverized toilet and a lot of water damage.
mhardy6647
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Usually a few days.Sounds like a slow death
The goal of the immunoconjugates was to abrogate the innate cell surface carbohydrate mediated toxicity of ricin but to use it as the payload attached to a monoclonal antibody to target cancer cells. It wasn't a new idea (dating back to Paul Ehrlich's "magic bullet" hypothesis), but our wrinkle was a very specific modification of the carbohydrate-binding subunit ("B chain") of ricin (as opposed to just chemically removing it and using only the toxic "A chain", which was what most researchers and companies had been doing) to minimize 'off target effects' (so to speak).
... but I digress.
PS No, it didn't work all that well in the clinic, but it was a great gig for a "glycobiologist" (which is what we call ourselves).
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I didn't have the chance to touch alkali metals at all even when I was a chemistry undergrad.
Killingbeans
Major Contributor
Me neither. It was only used for demonstration purposes, and the students weren't allowed to touch it. But it always just sat in a jar of mineral oil among all of the harmless stuff. Didn't take many brain cells, or the lack thereof, to plan a theft.
No it doesn’t however the brain cells seem to have been selectively distributed in my classmate.
It is a relatively slow death. It inactivates ribosomes, essentially halting protein synthesis (and thus every enzymatic reaction in the body), although it only impacts cells with carbohydrate moeities on their surfaces (which is most of them). Time to lethality depends on route of ingestion—oral—>inhaled—>parenteral. Even the IV route takes up to 72 hours to cause death. The prodrome is exceedingly unpleasant however; and it would be pretty hard to get much accomplished before you went feet up. I’m baffled as to why castor plants evolved this stealthy defense mechanism if the beans are so impenetrable that they pass through the GI tract undisturbed.Sounds like a slow death
Future anthropologists will be highly perplexed by the evolution of this thread. How did we get from snake oil to bioterrorism agents again?
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Based on your screen name there’s a very exciting ricin topic going on in this thread. Should I be alarmed that you and @Palladium have suddenly taken interest in this chemical warfare topic on the Snake Oil thread?
Killingbeans
Major Contributor
Nahh... My online nickname was inspired by this short animation back when I was young(er) and didn't realize how it would present itself later in life :
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Synchronicity! I’m left to wonder whether the animators had castor beans in mind? To me lima beans are much more my mortal enemies…Nahh... My online nickname was inspired by this short animation back when I was young(er) and didn't realize how it would present itself later in life
I’m obsessed with this today. This is a particularly depressing read…
forum.psaudio.com
Fuse direction for Pass amp and preamp
I am going to re fuse my Pass X250.8 and XP-32 with Synergistic Research purple fuses in a couple of days. I was hoping to get advice on a rule of thumb for direction of the fuses. My instinct tells me to start by installing the fuse by the direction of the lettering on the fuses. I am thinking...
forum.psaudio.com
mhardy6647
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mhardy6647
Grand Contributor
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- 24,778
Yeah -- it's only for DC fuses that it matters!
By the way, what happens if we use an AC fuse for DC?
It's bad, isn't it?
I’m obsessed with this today. This is a particularly depressing read…
Fuse direction for Pass amp and preamp
I am going to re fuse my Pass X250.8 and XP-32 with Synergistic Research purple fuses in a couple of days. I was hoping to get advice on a rule of thumb for direction of the fuses. My instinct tells me to start by installing the fuse by the direction of the lettering on the fuses. I am thinking...
That really is a depressing read. Not a hint of self awareness amongst the lot of them.
Fuses for DC when voltages are large enough can present a problem. Once the fuse blows under a fault condition in such a setting, the vaporized metal can form a plasma that keeps conducting and may start a fire. With AC, the zero-crossings allow the ark-over to stop and extinguish the continuous burn.
Killingbeans
Major Contributor
I’m obsessed with this today. This is a particularly depressing read…
Fuse direction for Pass amp and preamp
I am going to re fuse my Pass X250.8 and XP-32 with Synergistic Research purple fuses in a couple of days. I was hoping to get advice on a rule of thumb for direction of the fuses. My instinct tells me to start by installing the fuse by the direction of the lettering on the fuses. I am thinking...
I love how Paul of all people subtlety tried to make them use their brain a little, but got nothing but gibberish in return
As long as they keep plugging that I2S connector so he can sell more DirectStream/Perfectwave SACD/DAC combos.I love how Paul of all people subtlety tried to make them use their brain a little, but got nothing but gibberish in return