I have a pair of Vandersteen 3As run in bi-amp mode, and just got a V2W sub (with the line-level input to avoid messing around with speaker wires etc).
In stereo mode I had the 3As running as follows:
PC (lossless/hires sources) to Topping D10 DAC to Chase RLC-1 (as preamp) to Aragon 8008x5...