I realize I am replying to a year-old post, but having just received a BRU5, I can confirm that when the USB is connected to my desktop computer, I can hear a very high pitch noise from the speakers - quite faint. Not sure I would call it "wheezing" - it does not seem to interfere with evaluating the DSP changes I am making, and I disconnect the USB from the computer after I have committed the changes to the device.I understand that you are using an Asus Z99H Windows XP laptop to run ACPWorkbench. Is that true? That is 17 years old (which = 87 years old in Laptop Years). I expect you will wheeze a lot when you are 87I think it is very unlikely that anyone on AliExpress is using a laptop that old. That could be the problem. When you contact Wondom/Sure at https://store.sure-electronics.com/question/1 be sure to tell them about the laptop you are using.
Most of us use ACPWorkbench only briefly to make and save EQ changes. You do not have to be listening when you do this. If you cannot figure out the problem I think you can still use the software to make changes. Just disconnect your sound card from the Bru5 RCA audio inputs, make and save the changes, then turn off ACPworkbench before you play music again.
Other observations - I am awaiting a 36v 8A power supply, but temporarily put a laptop power supply into service that I used with a 3116 amp that this replaces. It is 19.5v 8a, and drives the BRU5 quite well. It will be interesting to see if more power brings any real audible change, or more heat. Subjectively, I get more gain out of this than the Nobsound 3116 unit using the same supply, though I think my EQ curve is introducing an overall gain. I was using a PC-based EQ with the 3116 that I have dispensed with.
I have little use for Bluetooth currently, but may try to add the ability to switch off at least the blue indicator LED.