I am aware that these have a few issues, from IMD, to limited SPL capability, and beaming at higher frequencies, but are they so poor at these aspects that single driver sets are basically a pointless design to consider? Or is there something else about them that makes them such an unattractive option measurement wise?
"Single drive" is not a recognizable term at all.
There is the full range speakers class in which the cabinet's acoustic design plays a key role (mainly these are varieties of a transmission line or a horn).
There is coaxial speakers class in which "single drive" means something else because a coax drive is not "single" to be true. These might just be a "little box", yes.
The first class has its own fans, but it's more about very experienced DIY designers because of cabinet assembly complication, all those folded horns require a lot of effort:
http://www.wodendesign.com/maeshowe.html (this is exactly what I did for myself and it's unforgettable).
Commercial production of such complicated in assembly cabinets is practically meaningless.
But driver manufacturers do not discontinue full-range drivers and even design new (Lowther, Markaudio, Fostex, SB Acoustics, Monacor, Tangband etc).
And then I have nothing to say, because I did not understand a goal of your question.
Are you about to design your speaker and don't know if it makes sense to go with full range design? If the question sounds like that, I will answer "yes, it makes sense".