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Consider trying an Aiyima A07, even though it is a class D amplifier. For around $80 (with power supply), I've been very impressed, and I do occasionally have audio fatigue from some amplifiers. Order from somewhere where you can return it if you don't like it.
I find that I have a coffee threshold for listening fatigue. If I drink more than a certain amount, I cannot enjoy the music. Once I attain a certain caffeine level, I think the sound sort of overloads my "circuits", synapses, or something else and the music starts to aggravate me. Too much input, I guess.
I wouldn't attribute fatigue to the electronics particularly (unless perhaps an insufficient amp being overdriven?) rather than the speakers/room/setup. I have a full set of the Studio 5 speakers (the 530s being rear surrounds), listen to them all the time, don't find them fatiguing at all myself.
