I don't know of it, but maybe they can be difference if only the circuitry of spidf optical and coax don't share the same input like opa1612, if i don't fail to remember some measurements of that type were different in coax vs optical, i hear someones says Coax sound better than optical, or maybe i'm just wrong!!
Cables don't do anything about frequencies: .. Mhhhhh, as i said in other forum, my 60€ qed toslink sounded defenately better to me instead of the 10€ Ivanky after few hours of testing them, they replied me it's all in my head, there aren't differences, only my fantasy, and i could do a blind test, as i can tell, i think a blind test could be even easier to catch the differences of those cables, but Anyway.. User reviews of expensive cables can talk too, a vast majority of users give them 5stars and report those 'expensive' cable can make huge differences in : improved soundstage, separation, smoother high, mids, lows, trasparency and that stuff.. Actually even reviews of specialized sites like Whathifi etc. who target award winning ones, says those cable writes differences of that kind, sound signature etc.. Just to point it out. . Now, here i have interesting video of an Italian guy who measured two RCA cables, one cheap 10€, and one very expensive, with beast shielding etc. of about 200-300, look, It can be very interesting with what are we talking!
At 12:00 he figure out the measurements, i don't know which graphs are them, i hope you can catch his Italian words to understand lol At 13:15 come very interesting, on his graphs, you could see substantially difference on SPL, higher 0,3db of SPL, (0,4% Higher SPL!) on the expensive cable vs cheap! And you could see almost huge differences in frequency response graph!! Look At that, i mean, we are talking around 3dB. differences in 60db graph!!!! That's a lot i think, you can see smoother lows and highs.. That could be one prove that out there cables really make a difference, i mean.. Look At that.. Tell me what you think, I would really like to know

About recording studio guys, i Wonder where to find what they really think about cables, and if they use it or not

Hope to be clear because my English is not perfect ;]