I installed it the old way, which still works fine on macOS. However, it automatically turned on after completing the update unlike before.
There are some changes for the display settings as well. There is now an Auto screen off setting that was set to 60 seconds by default. It can be set to 10 s, 30 s, 60 s and Never. Correspondingly, the brightness setting no longer includes Auto. Further, there is a "Screen off" setting, which can be set to "Input", which is as it was before under "Auto" brightness and is the default, and "Fully Off", which also turns off the backlight.
There are also some changes to the input, output, PEQ and crossfeed settings. The selections for the options to cycle through have been moved to Advanced > Cycle range > X option, where X is input etc. The PCM filters to cycle through can also be changed there under PCM option.
The manual has not been updated for FW V2.46 yet.