What are the speakers connected to? Since LO BAL is -50 dB, I don't quite understand how it's connected. Reduce the frequency to 44.1 and see if there is any hissing.
Speakers are connected to my 3e Audio A7 (the black void with the red light under the DX5 II in the video), which is connected to the DX5 II via XLR. It doesn't matter whether it's HPA or LO, the issue happens on either output. LO is only used for the video so that the issue is immediately audible. There's no reason for me to crank the volume for the test, so I kept it low out of politeness to my wife (but also, -50dB from less than 2ft away isn't that quiet to my ears IRL, and it's only about 5-10dB quieter than I normally keep it at any given time). That's why the DX5 II was set at -50dB. I have the D10s in the chain because it resolves a popping issue from my Mac's USB output (which I just discovered doesn't happen if I use a web-based source like Bandcamp or YouTube, it will only happen if I use the Mac's Music app or if I play a system notification sound). The D10s is merely acting as a bridge between my Mac and DX5 II (the D10s' DAC chip is bypassed in this configuration, so I'm not doubling up on DACs).
I honestly don't think it has anything to do with the sample rate because if I remove the D10s completely out of the chain, and only use the USB input on the DX5 II, the problem doesn't happen. Also, if I leave things as is, but sever the USB connection between my Mac and DX5 II, the issue does not occur. If I have things as they are, and set both OPT and USB as active in the Input Option menu, the issue also does not occur. I really do think it's because the DX5 II is searching for an input to switch to (i.e. USB in this case) that hasn't been made available in the settings because the DX5 II will auto-select the input regardless of how you have things set. I think that is what the bug is, and the hiss is a product of that.
That being said, I won't dismiss what you've suggested entirely, and I'll test dropping the sample rate down to 44.1kHz when I have the time this evening.
Edit:
@Mario1969 OK, so I conducted more tests, and dropped the sample rate down to 44.1kHz as you suggested. No hiss. Then raised it to 96kHz. No hiss. Then raised it to 176.4kHz. Hiss. I have another USB DDC (the SMSL PO100 Pro) that I will try out as well, and see if it's maybe the D10s that's the culprit. I did have an issue before where there was a whole lot of stuttering when setting the sample rate above 96kHz with the D50 III DAC. I'll test out the PO100 Pro, and report my findings as son as I can (I may not be this evening, though). Did all of this testing wearing my headphones, and I could immediately tell when the hiss was going to happen because when the devices woke up, there was a slight pop in the right channel, and around 10 seconds later, the hiss kind of sputters then fades in to its loudest state.
Edit 2:
I found much faster steps that eliminates all of the waiting. Using the same connection configuration I've previously outlined, only the following steps are required:
1. Play and pause any audio (once again, I used the Bandcamp website) -- this only needs to be for a few seconds.
2. Press the Power button on the remote to put the DX5 II into standby mode
3. Press the Power button on the remote to take the DX5 II out of standby mode
4. Wait about 10 seconds, and a hiss will occur in the Right channel
This issue requires PEQ Config to be enabled, and the Sample rate for the devices need to be set to 176.4kHz or 192kHz (the maximum allowable for the PEQ feature to be used). No hiss when set to 44.1 - 96kHz. I can rule out the D10s because the issue occurred even with the SMSL PO100 Pro -- that means any USB DDC can be used to test. Video attached below for the curious:
drive.google.com
Edit 3: I also discovered that no USB connection is required between the Mac and DX5 II for the issue to occur, which probably debunks my theory about it searching for a USB connection that is no longer available. So, I was mistaken.