So something else weird happened. I could not tell you the cause because it would have happened sometime between about 3am, and only about 5 minutes ago (the amount of time I've technically been away from the computer at home).
I noticed that even though my computer was going to sleep, it wasn't putting my D10s or DX5 II to sleep, so they have been on, almost constantly, since 3am. I say almost because I manually put the DX5 II into standby mode using the remote before leaving for work this morning because I noticed it was warmer than normal, and clearly hadn't turned off in 7 hours.
Anyway, I sat down, put on my headphones, and there was a low hiss in the right channel of my headphones. Switching outputs did not correct it (I didn't turn on my power amp to see if the hiss kept going, so I don't know if it's related to the HPA), unplugging the headphones also didn't, but turning the unit off from the switch on the back did. Yesterday was also the first day where I had been using the PEQ feature, but I'm not sure if that had anything to do with it or if it's the latest FW. I also disabled the USB input on the DX5 II as I discovered that I didn't need it to be an active input to be able to use Topping Tune or update the FW (a USB cable from the DX5 II is connected to my Mac, though). Prior to that, my D10s, and DX5 II were going to sleep regularly, but it's generally been inconsistent (and I attribute it to the Mac more than the Topping devices).
I'll try to keep tabs on this to see if I can figure it out. I can't submit anything to Topping without knowing what caused the problem. For now, I have disabled the PEQ in the DX5 II (the unit has cooled down a bit even in the time it's taken to write this post -- not that it was hot, it was definitely warmer than usual). If it happens again with it off, then it could be a HW issue.
Funny how I have these issues shortly after saying that the current state is functioning perfect...
Edit:
The only thing to maybe note is that when I put the DX5 II into standby this morning before going to work, my computer, and D10s were still on. I also couldn't tell you how long the DX5 II stayed in standby mode before something woke it up.