If the poster wants 16 synchronised analogue outputs then they would be better served by buyingThis is one of those "it depends" answers. In absolute terms, no they will not run synced. Even using the same PC, you would need a master clock to guarantee synchronization. In practice, you might not experience the consequences of non-synchronization.
16A | MOTU.com
The world’s first Thunderbolt 4 / USB4 audio interface connects to a Mac, PC or iOS device with low-latency, high-performance drivers to deliver 66 channels of audio I/O, superb analog performance driven by renowned ESS Sabre32™ DAC technology, 64-channel mixing, FX processing, AVB audio...