If you're sitting more than 3 times the largest dimension (of the speaker) away from the speaker you're fine.
? What does this even mean? The literal size of the speaker?
One 'rule of thumb' I know of is to place the MLP about 2/3-3/4 of the distance from the front wall (aka 1/3-1/4 from the rear wall). This is based on room mode characteristics of 'typical' rectangular rooms. AFAIK it has naught to do with the 'dimension of the speaker'.
Placement of the front speakers themselves is usually recommended to be an equilateral triangle (though certainly not absolutely required IME) , mindful of boundary effects on bass (though these can be either exploited, or can be corrected by room EQ) , and rear speakers of a 5.1 system placed circa 110 degree angle wrt MLP. These are only guidelines. Actual room measurements and use of e.g. REW would of course be even better.
Having an elaborate surround setup can work fine as long as you have an AVR that does good distance compensation and room (i.e. speaker) EQ, and good subwoofer placement. And the more point sources you have firing direct at you, the more the room is masked.
I like to use a set of audio test signals that locate left, center, right, half left, half right, side midpoints, left rear, right rear, right center etc, to fine tune position and aiming of speakers for accurate imaging.