I do believe that scientific instrumentation is capable of detecting sonic differences that are well below the threshhold of human "hearing". How our brains process those stimuli is fascinating, as is how our beliefs and personalities interpret our "perception" of sound. It's too bad we cannot measure highly variable neural "distortion" in our brains as easily as we can measure - and determine the audibility of - the distortion of signals in electro-mechanical systems.
Isn't this really the root of much of the disagreement in this hobby? Especially objective vs subjective stances. My interpretation of what the objectivist stance is, "this is what is coming out of this system" - That's all we are claiming, and that's all we can really do here on a mass level. How one's brain interprets those signals is too specific to the individual considering room, positioning and psychological factors.
The Subjective stance is equally valid in the final product - enjoying the sounds - but what your individual brain does with that information is not what is being presented here. We can only predict preferences based on statistical models. If you don't follow that model average, fine, but it doesn't change what your ears are receiving. It seems many that argue the subjectivist stance don't grasp this distinction.