In the United States, another toad species, Bufo alvarius, known as the Colorado River toad or the Sonoran Desert toad, causes similar effects. Although it isn't illegal to own a Colorado River toad in the United States, the active chemical in toad venom, bufotenine, is a controlled substance. This is the same chemical contained in cane toad venom. Bufotenine-related drug arrests reappeared in Southwestern states such as Arizona in the mid-1980s and '90s, following its original heyday in the 1960s.